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These are the excellent presentations from the Children with Cancer UK sponsored childhood cancer session organised by Professor Denis Henshaw for the 8th Princess Chulabhorn International Scientific Congress held in Thailand in November 2016.

Our highly successful 2017 conference concentrated on the latest in advanced treatments research. Our 2018 Conference is primarily concentrating on causal factors and prevention but we will also have updates on our current treatment projects and some other forms of treatment.

Cancer research - where now?  Signposts towards the future

There have been some excellent improvements in cancer treatment with more patients being cured or living longer lives and with less long-term adverse effects from treatment, but the overall war against cancer is stalling. Drugs targeted against specific genetic and proteomic markers will play an important role in the future. However, ten years of intense work on The Cancer Genome Atlas sequenced 10,000 malignant tumours and discovered about 10,000,000 cancer related mutations. (TCGA, 2006-2015)

A systematic study of cancer drugs approved by the European Medicines Agency in recent years found that most had no evidence of better survival or quality of life (doi:10.1136/bmj.j4530).

Fiona Goodlee, Editor in Chief of the BMJ recently wrote (5th Oct. 2017):
"The few drugs with evidence of benefit achieved only marginal gains."

The January 2018 issue of the Royal Society of Medicine Journal has a long article by Charles Swanton (Francis Crick Institute and UCL) which starts:
"The cost of cancer drugs since 1965 have increased from US$100 per month to US $10,000 per month. Unfortunately many of these novel anti-cancer drugs are not working any better than they were 40 or 50 years ago. If we take the 12 years between 2002 and 2014, of the 71 anti-cancer drugs that were approved, 23 of these had no overall survival benefit."

The percentage of children and young people with cancer who survive more than ten years has increased little since 2000, and those who do survive often have considerable personal health and life challenges. It is clear that we need to develop improved approaches and integrate changes that have been shown to help.

This challenging conference will explore evidence-based possibilities for change

Click on the speaker names for more information on each presentation


Day 1 - Wednesday 12th September 2018

The Metabolic Roots of Cancer and Introduction to causal factors
08:00 Open for registration (and posters)
09:15

Welcome and Session 1
Chair: Professor Denis Henshaw - Scientific Director Children with Cancer UK

09:30 Children with Cancer UK
Dhivya O'Connor - CEO Children with Cancer UK
What we have achieved over 30 years and our hopes for the future
09:45 Keynote address
Dr Annie Sasco - Ramazzini Fellow
Former-Director, Epidemiology for Cancer Prevention, INSERM (Emeritus)
Childhood cancer; do we have enough evidence to act now for prevention?
10:15 Alasdair Philips - Trustee Children with Cancer UK
Future Children with Cancer UK initiative and the purpose of this conference
Announcement of £2M Grant Call for research into causal factors and possible preventative actions
10:45 Refreshment break
11:15

Session 2 - The Metabolic roots of cancer
Chair: Alasdair Philips - Trustee Children with Cancer UK

11:20 Professor Thomas Seyfried - Morrissey College Boston, USA
Cancer as a Metabolic Disease: Implications for Novel, Non-Toxic Therapies
12:15 Q & A session
12:30 Professor Denis Henshaw - Scientific Director Children with Cancer UK     Ramazzini Fellow
Environmental and lifestyle factors affecting cancer risk in children and young people - epidemiology and mechanistic understanding
13:00 Lunch and Scientific Poster viewing
14:00

Session 3 - Introduction to causal factors
Chair: Dr Nick Goulden - Medical Director Children with Cancer UK

14:00 Dr Kurt Straif   -   Ramazzini Fellow
Head of Monographs, International Agency for Research on Cancer (IARC, WHO)
The multi-causal nature of Cancer and the IARC Monograph assessments.
Childhood Cancer: Descriptive Epidemiology, Risk factors and research Challenges
14:30 Professor Mathuros Ruchirawat   -   Ramazzini Fellow
Vice President for Research and Academic Affairs Chulabhorn Research Institute, Bangkok
The importance of international co-operation and team working
14:50 Comfort break
15:45

Chair: Alasdair Philips - Trustee Children with Cancer UK

15:15 Professor Catherine Metayer - University of California, Berkeley
Center for Integrative Research on Childhood Leukemia and other cancers and the Environment (CIRCLE) and the Childhood Leukemia International Consortium (CLIC)
International and Multidisciplinary Collaborations to Advance Etiologic Research on Leukemia and Other Cancers in Children
15:45 Pete Wilkinson - Environmental Policy Consultant
Founder & former Director of Greenpeace UK and leader of Greenpeace Antarctic Expeditions
Translating scientific evidence into meaningful and protective public policy
16:15 Chair plus panel (TBA)
Plenary workshop session - what are the key issues we need to address?
16:45 Scientific Poster Viewing (water and juice available in the Poster rooms)
Also, in parallel, an advanced medical discussion forum with Professor Thomas Seyfried
17:00 Drinks Reception and continued Poster viewing
18:30 Close of Day 1

Day 2 - Thursday 13th September 2018

The Environmental Causes of Cancer – The Evidence
08:15 Open for arrival and poster viewing
09:00

Session 5 – Assessing the evidence – Day 1

09:05 Dr. Fiorella Belpoggi - Head of Research, Ramazzini Institute, Italy    Ramazzini Fellow
'Multi-causality' – the essential need for "whole life" studies
Ramazzini's ELF and RF lifetime exposure studies on Sprague Dawley Rats
09:40 Professor Soterios Kyrtopoulos - National Hellenic Research Foundation, Athens, Greece
Blood-Based Omics Profiling and its Potential for the Study of Environmental Carcinogenesis
10:10 Professor Roberta Mckean-Cowdin - Clinical Preventive Medicine, USC USA
Brain Tumours in children and young people – what do we know about risk factors
10:40 Refreshments and poster viewing
11:15

Session 6 - Assessing the evidence – 2

11:20 Professor Jos Kleinjans - Head of NewGeneris European prospective mother-child study
Dietary and air-borne carcinogens and risk of childhood cancer
11:50 Associate Professor Marco Vinceti - Ramazzini Fellow     Director of CREAGEN, Modena, Italy.
Centre Environmental, Genetic & Nutritional Epidemiology of Modena & Reggio Emilia University

Traffic-related air pollution and risk of childhood leukaemia: A systematic review and dose-response meta-analysis
12:20 Professor Catherine Metayer - University of California, Berkeley
Center for Integrative Research on Childhood Leukemia and other cancers and the Environment
Clues to Increasing Trend of Childhood Leuk emia and Other Cancers in Some Populations
13:00 Lunch and poster viewing
14:00

Session 7 - Assessing the evidence – 3

14:00 Dr Juan Manuel Mejia Arangure - Children's Hospital, Federico Gomez, Mexico City, Mexico
Infection and acute leukaemia in a country with great migration and an increasing incidence of acute leukemias
14:30 Professor Cathy Vaillancourt - INRS-Institut Armand-Frappier, Université du Québec
Role of melatonin as a protective agent in utero
15:00 Professor Richard Stevens - University of Connecticut, Farmington, CT, USA
Electric light can disrupt circadian rhythms in children: is that a problem?
15:30 Comfort break
15:50

Session 8 - Assessing the evidence – 4

15:50 Dr Erica Mallery-Blythe - Physicians' Health Initiative for Radiation and Environment (PHIRE)
Cancer-related and biological justifications for minimising child IR and NIR radiation exposures
16:20 Update on Ionising radiation and child cancer - various speakers
16:50 Questions from the floor
17:00 Close of day 2
19:00 Speakers dinner

Day 3 - Friday 14th September 2018

Treating and Preventing Cancer – The Way Forward
08:15 Open for arrival and poster viewing
09:00

Session 9 – Update on treatment research    -    Chair: Dr Nick Goulden

09:00 Professor Steve Clifford - Director Northern Institute of Cancer Research
Progress report on the progress of the INSTINCT projects
09:20 Dr Ruman Rahman - Assistant Professor of Molecular Neuro-Ocology, University of Nottingham
Update on Nottingham Children's Brain Tumour Research Centre Drug Delivery Project
09:40 Professor Lou Chesler - Institute of Cancer Research, London
Progress report on the start of SMPaeds initiative
10:00 Professor Richard Grundy - Professor of Paediatric Neuro-Oncology and Cancer Biology, University of Nottingham
Update on our BIOMECA Project
10:20 Professor David Walker - University of Nottingham, Chair BTCI Biology Group
Preventing brain injury as a priority for brain tumour treatment research
10:40 Refreshments and comfort break
11:05

Session 10 - The Need for New Initiatives

11:05 Professor Steve Clifford - Director Director Northern Institute of Cancer Research
Thoughts on future opportunities in molecular survivorship - understanding treatment and disease-related toxicities and late-effects, and tackling these.
11:25 Professor Russel Reiter - Professor of Cell Biology, University of Texas, USA
The Association of Melatonin and Childhood Cancer with Particular Emphasis on Metastasis
12:05 Dr Mark Miller- Associate Clinical Professor of Paediatrics and Internal Medicine, UCSF
Director of the Children's Environmental Health Program at California EPA

Consequential Epidemiology and Children's Cancer
Including the need to reduce ongoing exposures to identified environmental toxic agents.
12:45 Pablo Kelly - GBM brain tumour survivor
He refused chemo and radiotherapy and used keto diets plus supplements and is doing well
13:00 Lunch - PLEASE take down and remove all Posters by end of lunchtime!
14:00

Session 11 - Integrated Approaches to child and young person cancer

14:00 Dr Andrew Tresidder - GP, medical lecturer and emotional health strategy trainer
The Emotional Effects of Cancer
14:25 Dr Lesley Howells - Research Lead - Maggie's Centres
Maggie's: Our contribution to holistic cancer care for children, young people and families.
14:50 Chris Woollams - Former Oxford University Biochemist and founder of Cancer Active (Charity)
Increasing your Personal Odds of Survival
This talk by Cancer Active opens up another side of the cancer causes and treatment debate. Cancer Active's very large public following shows that many people are dissatisfied with current NHS "Standard of Care". It presents the speaker's views and those of Cancer Active. Children with Cancer UK include it here to stimulate a wider debate.
15:50 What have we learned so far?
Summary and a Q & A session with a platform speaker panel
16:30 Close of conference

This page was last updated 26th June 2018

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